Trains between Reading and Paddington face their sixth consecutive weekend of disruption due to engineering works and crew availability.
There will be no trains between Paddington and Reading before 11.15am on Sunday.
After 11.15am, trains will run but services between London Paddington and Reading will be reduced as only two out of four tracks will be available.
Replacement buses are planned between Ealing Broadway and Slough.
Customers are advised to check on the day of travel as crew availability will result in additional short-notice cancellations or alterations, according to Great Western Railway.
The train operator has warned disruption is likely to affect services between London Paddington and Bristol, and local Bristol services, and London Paddington and Devon/Cornwall.
It will be the sixth Sunday in a row that the Reading-Paddington line has faced significant disruption.
Earlier in this month, the line saw 'a significantly reduced service' on the line between London and Bristol Temple Meads on Remembrance Sunday - when tens of thousands of people looked to travel to the capital for memorial events.
GWR warned customers to ‘only travel if absolutely necessary’ between London Paddington, Bristol, and South Wales the previous Sunday, November 3.
Train crew availability led to cancellations and disruptions on October 20 and 27.
And Network Rail is warning that more disruption is to be expected in the run up to Christmas.
Marcus Jones, Network Rail’s Western Route Director, said:“This November and December, we have a number of packages of engineering work in the Thames Valley area, which will unfortunately mean some disruption for passengers.
“Our work to improve the performance of the line in the Thames Valley is also well underway and we’ll be upgrading drainage systems and the track later in November and into early December. These upgrades are vitally important to ensure that we can continue to see positive changes.
“We have made good progress with our Thames Valley improvement plan, although there is more to do. These upgrades are essential to our goal of reducing disruption and improving the resilience of this stretch of line into the future.”
He added: “I’d like to thank passengers in advance for their patience. There’s never a good time to close the line, however we do try to ensure that any disruption takes place when fewer people are using the railway, such as at weekends."
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