Reading conceded a stoppage time strike to lose 2-1 at relegation rivals Leicester City.
In a cruch week for the Royals, a 2-2 draw with fellow strugglers Brighton and Hove Albion last week set up a clash with the Foxes.
Falling behind early to Sam Tierney, Charlie Wellings levelled the scores in first-half stoppage time.
Under pressure for most of the second half, Carrie Jones snatched the winner six minutes into stoppage time at the end of the game to earn a deserved victory and move them off of the foot of the Women's Super League.
Remaining 10th out of 12, Kelly Chambers' side are just two points clear of now-bottom Brighton.
Without an away win in the league all season, the likes of Aston Villa and Chelsea await in the final five fixtures as the women's side mirror the men's in battling to stay in their divisions approaching the closing stages of the season.
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